AMOXIL ®

 

How to use

For most infections in adults the dosing regimens for amoxil are 250 mg every 8 hours, 500 mg every 8 hours, 500 mg every 12 hours or 875 mg every 12 hours, depending on the type and severity of infection.

For the treatment of adults with gonorrhea the dose is 3 g given as one dose.

For most infections, children older than 3 months but less than 40 kg are treated with 25 mg/kg/day in divided doses every 12 hours, 20 mg/kg/day in divided doses every 8 hours, 40 mg/kg/day in divided doses every 8 hours or 45 mg/kg/day in divided doses every 12 hours depending on type and severity of the infection.

 

Drug Description

Amoxil is an antibiotic that belongs to a class of antibiotics called penicillins.

These antibiotics all have a similar mechanism of action. They do not kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall.

Amoxil is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci. Formulations of AMOXIL contain amoxicillin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically, it is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. It may be represented structurally as:

 

 

 

 

 

Warnings/Precautions

Before taking Amoxil, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies.

Before using this medication, tell the doctor or pharmacist your medical history, especially of: kidney disease, other infections (e.g., mononucleosis). This medicine may contain aspartame.

If you have phenylketonuria (PKU) or any other condition where you must restrict your intake of aspartame (or phenylalanine), consult the doctor or pharmacist regarding the safe use of this medicine.

This medication should be used only when clearly needed during pregnancy.Discuss the risks and benefits with your doctor. Amoxil passes into breast milk. Consult your doctor before breast-feeding.

 

Possible Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• diarrhea that is watery or bloody;
• fever, chills, body aches, flu symptoms;
• easy bruising or bleeding, unusual weakness;
• urinating less than usual or not at all;
• agitation, confusion, unusual thoughts or behavior; or
• seizure (black-out or convulsions).

Less serious side effects are more likely to occur, such as:

• nausea, vomiting, stomach pain;
• vaginal itching or discharge;
• headache;
• swollen, black, or "hairy" tongue; or
• thrush (white patches inside your mouth or throat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

 

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